When the commander of a U.S. nuclear submarine is ordered to fire on a foreign country, he refuses and the sub is declared an enemy of the state in this new series. Andre Braugher and Scott Speedman star. ABC/Global, 7 p.m.
Johnny Lee Miller teams with Lucy Liu in this modern-day take on Sherlock Holmes. Disgraced Londoner Holmes moves to New York where he works as a police consultant alongside a sober companion hired by his father. CBS/Global, 9 p.m.
The Big Bang Theory
In this season premiere, Wolowitz learns he can't even escape his mother in space. Miles above the Earth, he mediates an argument between his mom and Bernadette. Meanwhile, Raj's friends abandon him for their dates. CBS/CTV, 7 p.m.
Jay Leno: Liam Neeson, Lisa Lampanelli
David Letterman: Regis Philbin, Neil Young
George Stroumboulopoulos: Paul Henderson
Craig Ferguson: Anne Heche
Jimmy Fallon: Sofia Vergara, Damian Lewis
The Daily Show: Amar'e Stoudemire
Jimmy Kimmel: Selena Gomez, Tony Bennett
Conan O'Brien: Jake Gyllenhaal, Karen Gillan