Health Day - ONLINE EDITION

Scientists Reverse Type 1 Diabetes in Mice

Finding might lead one day to new ways to treat humans with blood sugar disease, researchers say

  • Print

SATURDAY, June 14, 2014 (HealthDay News) -- Scientists who reversed type 1 diabetes in mice say their results might lead one day to new ways to help people with the blood sugar disease.

Type 1 diabetes accounts for about 5 percent of all diabetes cases and is typically diagnosed in children and young adults. There is no cure for the disease, but it can be controlled by taking insulin.

In type 1 diabetes, immune system T-cells attack insulin-producing beta cells. In this study, University of Cincinnati researchers found that using an antibody called UT18 to stimulate a molecule called TLR4 prevented T-cells from attacking beta cells.

This approach reversed type 1 diabetes in a large percentage of non-obese mice that had just developed the disease, according to the study, which was to be presented Saturday at an American Diabetes Association meeting in San Francisco. Research presented at meetings has not been subjected to the peer-review process that most medical journals use, so it should be viewed as preliminary.

The key to reversing type 1 diabetes in mice is to catch the disease when it first develops, study leader Dr. William Ridgway said. He noted that the window of opportunity for treatment would be longer in humans, but would still be relatively brief. However, animal research findings often do not pan out in human trials.

This approach is different from most attempts to combat type 1 diabetes in that it does not directly target T-cells, according to Ridgway.

He said the therapy holds promise because one drug has already been approved by the U.S. Food and Drug Administration and others are under development.

More information

The U.S. National Library of Medicine has more about type 1 diabetes.

Fact Check

Fact Check

Have you found an error, or know of something we’ve missed in one of our stories?
Please use the form below and let us know.

* Required
  • Please post the headline of the story or the title of the video with the error.

  • Please post exactly what was wrong with the story.

  • Please indicate your source for the correct information.

  • Yes

    No

  • This will only be used to contact you if we have a question about your submission, it will not be used to identify you or be published.

  • Cancel

Having problems with the form?

Contact Us Directly
  • Print

You can comment on most stories on winnipegfreepress.com. You can also agree or disagree with other comments. All you need to do is be a Winnipeg Free Press print or e-edition subscriber to join the conversation and give your feedback.

You can comment on most stories on winnipegfreepress.com. You can also agree or disagree with other comments. All you need to do is be a Winnipeg Free Press print or e-edition subscriber to join the conversation and give your feedback.

Have Your Say

New to commenting? Check out our Frequently Asked Questions.

Have Your Say

Comments are open to Winnipeg Free Press print or e-edition subscribers only. why?

Have Your Say

Comments are open to Winnipeg Free Press Subscribers only. why?

The Winnipeg Free Press does not necessarily endorse any of the views posted. By submitting your comment, you agree to our Terms and Conditions. These terms were revised effective April 16, 2010.

letters

Make text: Larger | Smaller

LATEST VIDEO

Christmas Cheer Board hamper kickoff

View more like this

Photo Store Gallery

  • A  young goose stuffed with bread from  St Vital park passers-by takes a nap in the shade Thursday near lunch  –see Bryksa’s 30 day goose challenge Day 29-June 28, 2012   (JOE BRYKSA / WINNIPEG FREE PRESS)
  • Down the Hatch- A pelican swallows a fresh fish that it caught on the Red River near Lockport, Manitoba. Wednesday morning- May 01, 2013   (JOE BRYKSA / WINNIPEG FREE PRESS)

View More Gallery Photos

Poll

Should the federal government force band chiefs and councillors to disclose their salary information?

View Results

View Related Story

Ads by Google