The Canadian Press - ONLINE EDITION

Studies find 'young' blood rejuvenates aging mice's brains, brawn

  • Print

NEW YORK, N.Y. - Older mice got stronger, exercised longer and performed better mentally after they were injected with blood from young mice, or even just with a substance that's more abundant in younger blood, U.S. researchers found.

Someday, if more research goes well, this may lead to a way to treat some infirmities of old age in people. In the meantime, scientists have a warning for do-it-yourselfers.

"Don't try this at home," said Saul Villeda of the University of California, San Francisco, an author of one of three papers published online Sunday by the journals Nature Medicine and Science.

He worked with mice that were roughly the equivalent of people in their 20s and 60s. Researchers repeatedly injected the older mice with blood from either the younger animals or other aged mice. Those that got the young blood did better in learning and memory tests than the mice given the older blood. For example, they performed better at recalling where to find a submerged platform in a maze.

Villeda said the researchers are trying to figure out what's in the young blood that made the difference.

The two other papers, from Harvard University, focused on a substance that is more abundant in the blood of younger mice than old. That protein, called GDF11, is also found in human blood and its concentration also appears to decline with age, said Amy Wagers, an author on both papers.

On average, aging mice that got injections of it showed greater grip strength and more endurance on a treadmill than untreated mice.

The Harvard scientists also found that exposing older mice to the blood of younger mice produced more blood vessels and blood flow in the brain. Injections of GDF11 had a similar effect. Lee Rubin, a study author, said those results suggest further work may lead to a way to treat age-related mental decline and perhaps dementia in people.

Wagers and Villeda said it remains unclear whether GDF11 explains the results of Villeda's study. Wagers said she suspects other substances in blood can also help aging animals.

___

Malcolm Ritter can be followed at http://www.twitter.com/malcolmritter

Fact Check

Fact Check

Have you found an error, or know of something we’ve missed in one of our stories?
Please use the form below and let us know.

* Required
  • Please post the headline of the story or the title of the video with the error.

  • Please post exactly what was wrong with the story.

  • Please indicate your source for the correct information.

  • Yes

    No

  • This will only be used to contact you if we have a question about your submission, it will not be used to identify you or be published.

  • Cancel

Having problems with the form?

Contact Us Directly
  • Print

You can comment on most stories on winnipegfreepress.com. You can also agree or disagree with other comments. All you need to do is be a Winnipeg Free Press print or e-edition subscriber to join the conversation and give your feedback.

You can comment on most stories on winnipegfreepress.com. You can also agree or disagree with other comments. All you need to do is be a Winnipeg Free Press print or e-edition subscriber to join the conversation and give your feedback.

Have Your Say

New to commenting? Check out our Frequently Asked Questions.

Have Your Say

Comments are open to Winnipeg Free Press print or e-edition subscribers only. why?

Have Your Say

Comments are open to Winnipeg Free Press Subscribers only. why?

The Winnipeg Free Press does not necessarily endorse any of the views posted. By submitting your comment, you agree to our Terms and Conditions. These terms were revised effective April 16, 2010.

letters

Make text: Larger | Smaller

LATEST VIDEO

Drew Willy says team couldn't get anything going

View more like this

Photo Store Gallery

  • STDUP ‚Äì Beautiful West End  begins it's summer of bloom with boulevard s, front yards  and even back lane gardens ,  coming alive with flowers , daisies and poppies  dress up a backyard lane on Camden St near Wolseley Ave  KEN GIGLIOTTI  / WINNIPEG FREE PRESS  /  June 26 2012
  • A goose comes in for a landing Thursday morning through heavy fog on near Hyw 59 just north of Winnipeg - Day 17 Of Joe Bryksa’s 30 day goose challenge - May 24, 2012   (JOE BRYKSA / WINNIPEG FREE PRESS)

View More Gallery Photos

Poll

Will you miss Grandma Elm?

View Results

View Related Story

Ads by Google