A man in his 20s died early Sunday after being shot outside the Opera Ultralounge at Main Street and Bannatyne Avenue.
It's Winnipeg's ninth homicide of 2014. Police are not ruling out the possibility other people may have been injured.
Winnipeg police spokesman Cst. Jason Michalyshen said officers were summoned after a report about shots being fired and a group of men being involved in a confrontation in front of the Opera Ultralounge.
Paramedics transported one man to hospital, where he died.
"These injuries are consistent with being shot," Michalyshen said, noting an autopsy is pending.
"At this time, investigators are looking into the possibility that additional victims were involved."
Sunday morning, officers were seen outside the nightclub collecting evidence that included a black cap with a brim and a red-coloured clothing item.
Anyone with information is asked to contact police at 204-986-6508 or CrimeStoppers at 204-786-TIPS.