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Britain invites public to comment on rules allowing embryos made from DNA of 2 women, 1 man

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LONDON - Britain is inviting the public to weigh in on draft rules allowing scientists to create embryos using DNA from three people — a man and two women — to prevent mothers from passing on potentially fatal genetic diseases.

The latest public review should be the last step before politicians consider changing the law to let doctors offer the new fertilization techniques to patients. That would make Britain the first country in the world to allow the procedure to help people have children.

Britain's department of health said Thursday the government hopes to gather as many views as possible before introducing its final regulations. The proposed rules have been published online and the government is inviting people to respond by late May.

The public input isn't meant to debate whether the controversial techniques should be permitted. Instead, it concerns how they should be used to prevent relatively rare diseases caused by DNA defects in parts of the cell called mitochondria. Mistakes in the mitochondria's genetic code can result in diseases such as muscular dystrophy, epilepsy, heart problems and mental retardation.

Mitochondria are energy-producing structures outside the cell's nucleus. The new techniques involve removing the nucleus DNA from the egg of a prospective mother and inserting it into a donor egg, from which the nucleus DNA has been removed. That happens either before or after fertilization.

The resulting child ends up with the nucleus DNA from its parents, but the mitochondrial DNA from the donor. Scientists say the DNA from the donor egg amounts to less than 1 per cent of the resulting embryo's genes.

"Allowing mitochondrial donation would give women who carry severe mitochondrial disease the opportunity to have children without passing on devastating genetic disorders," Dr. Sally Davies, the chief medical officer, said in a statement.

Last year, Britain's fertility regulator said it found broad public support for the technology, but some concerns were raised about safety.

British law currently forbids altering a human egg or embryo before transferring it into a woman, and such treatments are only allowed for research purposes in a laboratory.

The department of health said it hopes legislation will be in place so patients can receive the treatment by the end of the year.

When mitochondrial donation was first reportedly used to create an embryo in a British laboratory in 2008, tabloid headlines declared scientists had created a child with three parents — two biological mothers and a father. But scientists said that was inaccurate, since there are only trace bits of genetic material from one woman.

If the procedure is approved by Parliament, experts say it would likely only be used in about a dozen British women every year.

"Genetic alteration of disease risk is an important step for society and should not be taken lightly," said Dr. Peter Braude, an emeritus professor of obstetrics and gynecology at King's College London. But he said the proposed regulations would ensure the techniques would be limited to informed couples with personal experience of mitochondrial diseases.

Similar experiments are being conducted in the United States, where the embryos are not being used to produce children but only for research purposes. This week, the U.S. Food and Drug Administration held a meeting to discuss the techniques and genetic experts warned it could take decades to confirm their safety.

Critics have slammed it as a breach of medical ethics and said women at risk of passing on mitochondrial diseases already have other safe ways of having children, such as using donated eggs.

Human Genetics Alert, a secular group in Britain that opposes many genetics and fertilization experiments, has called the techniques a slippery slope that could lead to "a designer baby market."

"The techniques have not passed the necessary safety tests, so it is unnecessary and premature to rush ahead with legalization," said David King, the group's director.

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Online:

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