Buffalo's Marcus Foligno went to the tough area in front of the Jets' net and tipped in the goal that opened the floodgates for the Sabres early in the third.
Two goals 36 seconds apart give rookie Mark Scheifele three in the last two games and six on the year.
Free Press 3 Stars
Jets 2 at Sabres 4
Penalties -- Thorburn Wpg (interference) 9:29, Enstrom Wpg (delay of game) 11:00, Stafford Buf (tripping) 16:16.
1. Winnipeg, Scheifele 5 (Clitsome) 1:02.
2. Winnipeg, Scheifele 6 (unassisted) 1:38.
3. Buffalo, Ott 4 (Stafford, Weber) 10:16.
Penalties -- Little Wpg (Illegal Check to Head Minor) 14:59.
4. Buffalo, Foligno 4 (Hodgson, Myers) :50.
5. Buffalo, Moulson 12 (Ehrhoff, Ennis) 2:31 (pp).
6. Buffalo, Ellis 1 (Porter, Flynn) 13:38.
Penalties -- O'Dell Wpg (hooking) 2:11, Stafford Buf (roughing) 16:02, Clitsome Wpg (roughing) 16:02.
Referees -- Steve Kozari, Frederick L'Ecuyer. Linesmen -- Derek Amell, Brad Kovachik.
Attendance -- 17,795.
ON THE SLIDE:
In the last two weeks, the Jets have lost five damaging games that has dampened enthusiasm considerably about the playoff picture.
But the standings show that the team has slid just two points off the mark where it was on Nov. 24. Then, Winnipeg was eight points out of a Western Conference playoff spot. After Tuesday's loss in Buffalo, the Jets were 10 back of eighth-place Minnesota.
ON THE SIDE:
Scratched for the Jets on Tuesday were centre James Wright, who had the flu, defenceman Keaton Ellerby for the third straight game, and left-winger Anthony Peluso, who was serving Game No. 2 of his three-game suspension for boarding Dallas's Alex Goligoski last Saturday.
Wright's illness opened the door for centre Eric O'Dell to play his first NHL game. O'Dell is the St. John's IceCaps' leading scorer so far this season.
The Jets are home for one game, Friday against the Florida Panthers. (7 p.m., TSN Jets, TSN 1290).