A spine-zapping implant helped 3 people with a muscle-wasting disease walk better

Advertisement

Advertise with us

WASHINGTON (AP) — Three people with a muscle-destroying disease destined to worsen got a little stronger – able to stand and walk more easily – when an implanted device zapped their spinal cord.

Read this article for free:


or

Already have an account? Log in here »

To continue reading, please subscribe:

Subscribe and receive a limited-edition Free Press branded hat or tote.

Digital Subscription

One year of digital access for only $205*

  • Enjoy unlimited reading on winnipegfreepress.com
  • Read the E-Edition, our digital replica newspaper
  • Access News Break, our award-winning app
  • Play interactive puzzles

*First annual payment billed as $205.00 + GST for one year. This annual subscription will automatically renew at $233.00 + GST every 52 weeks (10% off the regular annual price of $259.35). Offer available to new and qualified returning subscribers only. Cancel any time.

To continue reading, please subscribe:

Add Free Press access to your Brandon Sun subscription for only an additional

$1 for the first 4 weeks*

  • Enjoy unlimited reading on winnipegfreepress.com
  • Read the E-Edition, our digital replica newspaper
  • Access News Break, our award-winning app
  • Play interactive puzzles
Start now

*Your next Brandon Sun subscription payment will increase by $1.00 and you will be charged $17.95 plus GST for four weeks. After four weeks, your payment will increase to $24.95 plus GST every four weeks.

Hey there, time traveller!
This article was published 05/02/2025 (608 days ago), so information in it may no longer be current.

WASHINGTON (AP) — Three people with a muscle-destroying disease destined to worsen got a little stronger – able to stand and walk more easily – when an implanted device zapped their spinal cord.

On Wednesday, researchers reported what they called the first evidence that a spine-stimulating implant already being tested for paralysis might also aid neurodegenerative diseases like spinal muscle atrophy – by restoring some muscle function, at least temporarily.

“These people were definitely not expecting an improvement,” said Marco Capogrosso, an assistant professor at the University of Pittsburgh who led the research. Yet over the month-long pilot study, “they were getting better and better.”

This image from video provided by UPMC and University of Pittsburgh Health Sciences shows Doug McCullough, who has spinal muscular atrophy, during tests of experimental spinal cord stimulation to improve muscle function in Pittsburgh, on March 14, 2023. (UPMC, University of Pittsburgh Health Sciences via AP)
This image from video provided by UPMC and University of Pittsburgh Health Sciences shows Doug McCullough, who has spinal muscular atrophy, during tests of experimental spinal cord stimulation to improve muscle function in Pittsburgh, on March 14, 2023. (UPMC, University of Pittsburgh Health Sciences via AP)

Spinal muscle atrophy or SMA is a genetic disease that gradually destroys motor neurons, nerve cells in the spinal cord that control muscles. That leads muscles to waste away, especially in the legs, hips and shoulders and sometimes those involved with breathing and swallowing. There is no cure. A gene therapy can save the lives of very young children with a severe form of the disease, and there are some medicines to slow worsening in older patients.

Stimulating the spinal cord with low levels of electricity has long been used to treat chronic pain but Capogrosso’s team also has tested it to help people paralyzed from strokes or spinal cord injury move their limbs unaided. While turned on, it zaps circuits of dormant nerves downstream of the injury to activate muscles.

Then Capogrosso wondered if that same technology might help SMA in a similar way — by revving up related sensory nerves so they wake up damaged muscle cells, helping them move to combat wasting.

The Pitt researchers implanted electrodes over the lower spinal cord of three adults with SMA and tested their muscle strength, fatigue, range of motion and changes in gait and walking distance when the device was firing and when it was turned off.

It didn’t restore normal movement but with just a few hours of spinal stimulation a week, all quickly saw improvements in muscle strength and function, researchers reported in the journal Nature Medicine.

“With a progressive disease you never get any better,” said study participant Doug McCullough, 57, of Franklin Park, New Jersey. “Either you’re staying stable or getting worse. So having any improvement is just a really surreal and very exciting benefit.”

All three participants significantly increased how far they could walk in six minutes, and one who initially couldn’t stand from a kneeling position could by the study’s end, Capogrosso said. And McCullough’s gait changed so that each step was about three times longer.

“They get less fatigued so they can walk for longer,” Capogrosso said. “Even a person this many years into the disease can improve.”

Intriguingly, researchers found the improvements didn’t disappear as soon as the stimulator was switched off, though they did fade as participants were tracked after the study ended.

McCullough said even when the stimulator was turned off, some nights his legs “would just feel supercharged.”

While he understood that the device had to be removed at the study’s end, he was disappointed. He said there were some lingering benefits at his six-week checkup, but none after six months.

Neuroscientist Susan Harkema, who led pioneering studies of stimulation for spinal cord injuries while at the University of Louisville, cautioned the new study is small and short but called it an important proof of concept. She said it’s logical to test the technique against a list of muscle-degenerating diseases.

“Human spinal circuitry is very sophisticated – it’s not just a bunch of reflexes controlled by the brain,” said Harkema, now with the Kessler Foundation, a rehabilitation research nonprofit. “This is a very solid study, an important contribution to move forward.”

At Pitt, Capogrosso said some small but longer studies are getting underway.

___

The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Science and Educational Media Group and the Robert Wood Johnson Foundation. The AP is solely responsible for all content.

Report Error Submit a Tip

More Stories

Band keeps plight of MMIWG close to heart on new track

Ben Waldman 6 minute read Preview

Band keeps plight of MMIWG close to heart on new track

Ben Waldman 6 minute read 2:00 AM CDT

Gabrielle Fontaine won’t stop talking about them and neither will her bandmates.

As a teenager, the Winnipeg songwriter — whose late father Vince was the passionate leader of musical projects including Eagle & Hawk — would volunteer at Wiping Away the Tears, an annual gathering hosted by Ka Ni Kanichihk that offers space for healing, ceremony and support for relatives of missing and murdered Indigenous women, girls and two-spirit people.

Though Indigenous people make up less than five per cent of the Canadian population, Indigenous women make up 16 per cent of all female homicide victims and 11 per cent of missing women, according to the Assembly of First Nations.

Seeking a way to help in the community, Fontaine regularly volunteered as a child-minder during memorial events, an experience she says shaped her outlook as a musical storyteller.

Read
2:00 AM CDT

Sidney Crosby sings praises of Jets' Bjorck, summer training partner Barron

Ken Wiebe 6 minute read Preview

Sidney Crosby sings praises of Jets' Bjorck, summer training partner Barron

Ken Wiebe 6 minute read Yesterday at 5:06 PM CDT

PITTSBURGH — It wasn’t that long ago when the shoe was on the other foot for Sidney Crosby.

Read
Yesterday at 5:06 PM CDT

Real journalists matter in an AI world

Paul Deegan 4 minute read Preview

Real journalists matter in an AI world

Paul Deegan 4 minute read 2:00 AM CDT

An algorithm can decide what you see, but it doesn’t report the news. Nunatsiaq News, an award-winning newspaper in Nunavut, recently reported that a so-called “news” website was posting AI-generated articles about the north by stealing real news stories produced by real journalists.

The articles were supposedly written by Nunavut correspondent Leah Qammaniq — a fake journalist, with a fake photo and a fake bio.

Governor General Louise Arbour warned us of fake news in her installation speech in June. She said, “We must continue to protect the public space in which our national debates take place: from schools and universities to the media, political parties, unions and civil society organizations …With instant access to vast amounts of information, it is very tempting to pay little attention to the reliability of sources. The lines between knowledge and belief, between truth and falsehood, between facts and assumptions, are increasingly blurred. AI could be threatening not only the way we live and work, but also the control we exercise over our own destiny.”

The Government of Canada has recognized the problem as well. Its recent discussion paper, Enhancing trust in artificial intelligence through increased transparency, stated, “Canadians encounter news reporting, product reviews, and audio-visual content across the internet, often without any indication of whether it was written by a person, generated by an AI system, or produced through some combination of both … A particular concern within this broader landscape is that generative AI greatly enables the creation and dissemination of deceptive or misleading content.”

Read
2:00 AM CDT

Former host/VJ Rick Campanelli revisits his gambling addiction in new memoir

Jen Zoratti 7 minute read Preview

Former host/VJ Rick Campanelli revisits his gambling addiction in new memoir

Jen Zoratti 7 minute read Yesterday at 6:00 AM CDT

To many Canadians, veteran media personality Rick Campanelli is better known as Rick the Temp, the energetic, baby-faced intern-turned-VJ on MuchMusic in the 1990s and early 2000s.

But behind that winning smile was a much darker reality.

In his new memoir, Tempted: My Story, released last month via HarperCollins Canada and co-written with John Meyer, Campanelli, 56, opens up for the first time about his struggles with a serious — and secret — gambling addiction, which reached its nadir in 2008 when the then-host of Entertainment Tonight Canada was detained by U.S. Homeland Security for unpaid casino debts on a flight back from Las Vegas.

The Free Press caught up with Campanelli in advance of his Winnipeg launch Monday evening at McNally Robinson Grant Park. This interview has been lightly edited for length and clarity.

Read
Yesterday at 6:00 AM CDT

Stevenson set for first Jets start against Penguins

Ken Wiebe 5 minute read Preview

Stevenson set for first Jets start against Penguins

Ken Wiebe 5 minute read Sunday, Oct. 4, 2026

DETROIT — Clay Stevenson, the stage is yours.

As the Winnipeg Jets wrap up a two-game road trip on Monday against the Pittsburgh Penguins, the newest member of the team will be between the pipes after Stuart Skinner got the call in the first two outings of the campaign.

There will be an element of familiarity for Stevenson, as PPG Paints Arena is where he made his first NHL appearance with the Washington Capitals on April 17, 2025.

“There is some comfortability in that building,” said Stevenson, who made 33 saves in a 5-2 loss to the Penguins in that NHL debut. “It’s always a great challenge to play against (Sidney) Crosby and (Evgeni) Malkin and those guys. It’s an honour to get into the crease anytime.”

Read
Sunday, Oct. 4, 2026

Seven Wilsons, one regional spirit

Hersh Seth 5 minute read Preview

Seven Wilsons, one regional spirit

Hersh Seth 5 minute read 2:00 AM CDT

In Dryden, Ont., a 34-metre suspension bridge crosses the Wabigoon River rapids. It is named after a man who paid for a quarter of the bridge himself. A plaque recognizes Roy Wilson’s “many contributions to City Revitalization” and mentions his 40 years in the Rotary Club, whose motto is “service above self”.

My father sold business machines from the 1970s through the ’90s, during the shift from carbon copy machines and typewriters to photocopiers, fax machines, and early office computers and printers. His sales territory — which he covered mostly by car but also by propeller plane — was Saskatchewan, the Northwest Territories, Manitoba, and northwestern Ontario, though much of it really belonged to the Wilsons.

In business machines, selling the machine was only half the job — the other half was ensuring a technician would fix it in January. Wilson’s set the standard for dealers across most of my dad’s regions. My father worked with Roy’s son Greg (who would later go on to become mayor of Dryden) but really respected Roy for teaching Greg to run the company with the towns they served as the priority.

Wilson’s service routes went beyond where roads stopped. Even if customers lived north of the highway system, Wilson’s still found a way to help, using three company planes based at the Dryden airport. As a result, a stationery shop from a paper mill town served all of northwestern Ontario and later northern Manitoba. Imagine a photocopier strapped into a small plane, a technician beside it, and a gravel runway waiting at the other end.

Read
2:00 AM CDT