Trey Mancini retires after a 5-game Angels comeback, ending a cancer survivor’s MLB run

By: The Associated Press Posted: 1:40 PM CDT Tuesday, Aug. 18, 2026

ANAHEIM, Calif. (AP) — Trey Mancini, the AL Comeback Player of the Year in 2021 for his return from colon cancer who then helped Houston win the 2022 World Series, announced his retirement Tuesday after his latest comeback lasted five games with the Los Angeles Angels.

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“Thank you, baseball,” Mancini wrote on lnstagram.

Mancini, 34, agreed to a minor league contract with the Angels in February, a deal that included an invitation to major league spring training. Mancini hit .273 with six homers, 29 RBIs and three steals for Triple-A Salt Lake this year.

FILE - Baltimore Orioles' Trey Mancini tips his helmet as fans give him a standing ovation prior to a baseball game against the Boston Red Sox, April 8, 2021, on Opening Day in Baltimore. (AP Photo/Julio Cortez, File)

The right-handed batter had three hits in his first major league game since 2023 playing first base in a 5-4 loss to the Houston Astros in 10 innings. Mancini’s final major league appearance was June 14, and he was designated for assignment on June 17.

“I am blessed to have made a home in the Orioles organization for 10 years, win a World Series in Houston, play for the Cubs in Chicago (I wish I played better for you guys), and make it back up to the MLB with the Angels,” Mancini wrote while also thanking the Reds, Marlins and Diamondbacks as well.

Mancini batted .263 with 129 homers and 404 RBIs in the majors. He played parts of six seasons with the Orioles and hit a career-high 29 homers in 2019.

He then missed the 2020 season after surgery to remove a malignant tumor from his colon. He made a successful return to the Orioles in 2021, and he won a World Series ring in 2022 after Baltimore traded him to Houston.

Mancini spent part of the 2023 season with the Chicago Cubs. He has since played in the minor league systems of the Reds, Marlins and Diamondbacks. He opted out of a minor league deal with Arizona last July after batting .308 with 16 homers for Triple-A Reno.